Ongoing Research Support
P30GM122732 Chen (PI) 09/01/17-08/31/22
Center of Biomedical Research Excellence in Skeletal Health and Repair
The goal of this project is to transition a multi-disciplinary research center to treat cartilage joint diseases.
Role: PI
R01 AR-072027 Y. Chen (PI) 9/1/17-8/31/22
NIH/NIAMS
Developing Nanomaterial Platform for Intra-Cartilage Delivery of RNA Therapeutics against Joint Diseases
The goal of this research is to develop a nanomaterial platform to treat joint diseases and symptoms.
Role: Co-Investigator
1 R61/R33 AR076807 Chen (PI) 9/1/19-8/31/22
Repressing Retrotransposon LINE-1: New Concepts for Osteoarthritis Treatment
The scientific goal of this project is to determine whether retrotransposon Long Interspersed Nuclear Element-1 (LINE-1), which is repressed in normal somatic cells but de-repressed during aging, contribute to aging-associated OA.
Role: PI
3P30GM122732-05S1 Chen (PI) 9/1/21-8/31/22
Developing Brain Theranostics of ADRD infiltrating the Blood-Brain Barrier
The focus of this COBRE supplement project is to develop a novel siRNA theranostics crossing the BBB using the Nanopieces (NP) technology for the treatment of ADRD.
Role: PI
1 R41 TR002298-01A1 Chen (PI) 3/1/20-2/28/22 (no cost extension)
STTR: Developing Nanopieces, a Platform RNAi Delivery Technology for Treatment of Multiple Diseases
The goal of this project is to develop drug delivery in difficult-to-reach matrix-rich tissues with a new generation of platform RNA delivery vehicle nanopieces.
Role: PI
NIH/NIAMS, R61AR076807-02S1 Chen (PI) 09/01/20-08/31/22 (no cost extension)
Determining the Role of Retrotransposon Line-1 in Alzheimer’s Disease
The scientific goal of this project is to determine whether retrotransposon Long Interspersed Nuclear Element-1 (LINE-1), which is repressed in normal somatic cells but de-repressed during aging, contribute to aging-associated AD.
Role: PI
Completed Research Support
3P30GM122732-04S1 Chen (PI) 9/1/20-8/31/21
Developing Brain Theranostics of ADRD infiltrating the Blood-Brain Barrier
The focus of this COBRE supplement project is to develop a novel siRNA theranostics crossing the BBB using the Nanopieces (NP) technology for the treatment of ADRD.
Role: PI
3P30GM122732-03S1 Chen (PI) 9/1/19-8/31/20
Developing novel Alzheimer's disease RNA therapeutics crossing the blood-brain barrier
The focus of this COBRE ADRD pilot project is to develop a novel ADRD RNA therapeutics crossing the BBB using the Nanopieces (NP) technology, the nucleic acid therapeutics delivery platform established in the COBRE Nanomedicine Core.
Role: PI
R01-AR066746-01A1 Yang (PI) 09/21/15-08/31/20
ROLE OF PTPN11 IN CARTILAGE STEM CELLS AND TUMORIGENESIS
The goal of this project is to study how the property of cartilage stem cells is regulated by the protein tyrosine phosphatase SHP2 under physiological and pathological conditions
Role: Co-Investigator
R01CA166089-01A1 Terek (PI) 09/25/13-07/31/19
Targeting CXCR4 and microRNA as Therapy
The goal of this project is to develop therapy to treat chondrosarcoma.
Role: Co-Investigator
P20 GM104937 Chen (PI) 09/15/12-08/31/17
Center of Biomedical Research Excellence in Skeletal Health and Repair
The goal of this project is to sustain a multi-disciplinary research center to treat cartilage joint diseases.
Role: PI
R01 AR 059142-01A1 Wei (PI) 04/01/11-01/31/16
Histone Deacetylation Regulates Growth Plate Development
The goal of this project is to understand how HDAC4 regulates growth plate development by CaMKIV, P38 MAPK, and miR-1.
Role: Co-Investigator
Rhode Island Research Alliance Collaborative Grant Award Chen (PI) 07/01/14-06/30/15
Novel SiRNA Delivery Technology via Biomimetic Nanomaterial for Treatment of Joint Arthritis
The goal of this project is to develop therapy to treat joint arthritis.
Role: PI
R01 AG 017021 Chen (PI) 09/01/98-02/28/14
Biophysical Regulation of Chondrocyte Differentiation
The major goals of this project are to study the effect of mechanical stress on chondrocyte properties
Role: PI
1 P20 RR024484 Chen (PI) 09/01/07-07/31/12
Center of Biomedical Research Excellence in Skeletal Health and Repair
The goal of this project is to establish a multi-disciplinary research center to treat cartilage joint diseases.
Role: PI
3P20RR024484-03S1 Chen (PI) 08/20/09-08/19/2012
ARRA Supplemental Fund to COBRE in Skeletal Health and Repair
The goal of this study is to develop translational strategies to treat chemokine induced joint diseases.
R01 AG 014399 Chen (PI) 02/01/97-12/31/11
Stabilization of Matrix Structure in Mature Cartilage
The goal of this project is to analyze the mechanisms that stabilize cartilage matrix structure
Role: PI
